Lin JY, et al. - Researchers focused on the prognostic implications of negative lymph nodes (NLNs) in gallbladder cancer (GBC). Using the Surveillance, Epidemiology, and End Results Program-registered TNM stage database, they obtained information regarding clinicopathological features and survival times of patients who had undergone surgery for GBC. Predictors of survival were determined using univariate and multivariate Cox proportional hazards models. They noted that, when evaluating the relation to survival, a cutoff of one to two NLNs was optimal, survival rates being consistently better with two or more NLNs than with fewer than two. A better 5-year gallbladder cancer cause-specific survival was reported in patients with two or more NLNs vs those with fewer than NLNs examined for stage I/II, stage III/IV, and all TNM stages. The number of NLNs was identified as an independent prognostic factor post-GBC surgery, and, better prognostic information could be obtained taking into account the number of positive lymph nodes together with number of NLNs, compared to the number of positive lymph nodes alone.