Baikpour M, Ozturk1 A, Dhyani M, et al. - In this study, the accuracy of portal vein pulsatility for noninvasive diagnosis of high-risk nonalcoholic fatty liver disease (NAFLD) was measured. Researchers designed a retrospective study involving individuals with a biopsy-proven diagnosis of NAFLD who underwent a Duplex Doppler ultrasound assessment of the main portal vein within 1 year of liver biopsy between January 2014 and February 2018. They reviewed doppler ultrasound images. They enrolled 123 participants. Thirty-three out of 123 participants had high-risk NAFLD and were found to have a lower venous pulsatility index (VPI) than the other 90 participants. For high-risk NAFLD VPI, they noted that NAFLD FS, FIB-4, and APRI had statistically significant diagnostic values. VPI was noted as the highest optimism-corrected AUC. VPI can be considered as an accurate noninvasive biomarker for the diagnosis of high-risk NAFLD.