Populational trends and outcomes of postoperative radiotherapy for high-risk early-stage cervical cancer with lymph node metastasis: Concurrent chemo-radiotherapy vs radiotherapy alone
American Journal of Obstetrics and Gynecology Nov 10, 2019
Matsuo K, Nusbaum DJ, Machida H, et al. - Researchers examined how concurrent chemotherapy use in women with early-stage cervical cancer and nodal metastasis receiving adjuvant radiotherapy influence their survival. Using the Surveillance, Epidemiology, and End Results Program from 1988-2016, they assessed 2,538 women with stage T1-2 cervical cancer with pelvic lymph node metastasis who underwent hysterectomy and received postoperative radiotherapy. Among these women, they observed a marked increase in the use of concurrent chemotherapy from 1997-2000 followed by a more gradual rise through 2016. As per the multivariable model, women with non-squamous cell carcinomas and those diagnosed more recently more frequently received CCRT, while older women less frequently received CCRT. Outcomes revealed no correlation between the use of concurrent chemotherapy during postoperative radiotherapy and improved survival despite the marked increase in the use of CCRT for women with early-stage cervical cancer and nodal metastases.
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