Archary M, et al. - The intention of the authors was to determine the therapeutic outcomes of lopinavir (LPV) in HIV-infected children admitted with severe acute malnutrition. They also explored the population pharmacokinetics of LPV in such children. It was determined that LPV pharmacokinetics was affected by fat-free mass and not by the timing of antiretroviral treatment (ART) initiation or tuberculosis comedication in severely malnourished HIV-infected children. Data displayed that LPV pharmacokinetics was highly variable and bioavailability greatly reduced, leading to a high clearance (CL) estimate in the cohort.