Benzerdjeb N, et al. - Since human papillomavirus (HPV) status and p16 status are as yet unclear among PDNECs, owing to a lack of statistical analysis. This study was undertaken to assess their potential clinicopathological relations, and their prognostic impact on overall survival in PDNECs of the head and neck, regardless of the HPV genotype. Between 1998 and 2019, all cases of PDNEC of the head and neck were distinguished from the database of the Lyon university hospital pathology department (n = 21); for these cases, p16 immunohistochemistry and HPV in-situ hybridization were conducted. In PubMed, published cases of PDNEC of the head and neck with the assessment of HPV status and p16 status were distinguished. The results of this study indicated that HPV+ tumour status was correlated with oropharyngeal PDNECs and with a better prognosis.