Konishi T, et al. - Common histologic markers at the invasive front of colon adenocarcinoma were compared in terms of prognostic accuracy and interobserver agreement. Researchers analyzed poorly differentiated clusters (PDCs), tumor budding, perineural invasion, desmoplastic reaction, and Crohn-like lymphoid reaction at the invasive front, as well as the World Health Organization (WHO) grade of the entire tumor, among consecutive patients who underwent curative resection for stages I to III colon adenocarcinoma from 2007 to 2014 at a single institution. Findings suggested PDCs be the best invasive-front histologic marker in terms of prognostic accuracy and interobserver agreement. PDCs seemed to have a potential for replacing WHO grade as a prognostic indicator.