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Polyphenol intake and differentiated thyroid cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

International Journal of Cancer Feb 08, 2020

Zamora-Ros R, Cayssials V, Franceschi S, et al. - In a European population, researchers assessed the risk of differentiated thyroid cancer (TC) and its main subtypes, papillary and follicular, in relation to intakes of total, classes and subclasses of polyphenols (bioactive compounds with several anticarcinogenic activities). There were 476,108 men and women in the European Prospective Investigation into Cancer and Nutrition cohort, who were recruited from 10 European countries. A mean follow-up of 14 years was performed. Experts found no link between total polyphenol and the risks of overall differentiated TC, papillary or follicular TC, in multivariable-adjusted Cox regression models. Either for flavonoids, phenolic acids or the remaining classes and subclasses of polyphenols, no links were found. People with BMI ≥ 25 showed an inverse link between the consumption of polyphenols and phenolic acids and differentiated TC risk, following stratification by BMI. Overall, findings revealed no links between dietary polyphenol consumption and differentiated TC risk but further investigations are justified to inquire about the potential protective links in overweight and obese people.
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