Shmuel S, Lund JL, Alvarez C, et al. - Researchers performed this prospective community-based cohort study in white and African American adults aged 50 to 95 years (n = 1,697) living in Johnston County, North Carolina, to measure the prevalence of frailty and polypharmacy as well as to estimate the link between polypharmacy and incident frailty. In 1,697 individuals, the prevalence of annual polypharmacy (5-9 medications) and excessive polypharmacy (≥ 10 medications) was calculated at the 2006-2010 visit. At two consecutive visits (2006-2010 and 2013-2015), prevalent and incident frailty were recorded by operationalizing the Fried frailty phenotype. Participants who were white, women, and had less educational attainment had a more common prevalence of frailty vs those without these features. In line with the current weight of evidence, a link between polypharmacy and incident frailty was suggested.