Growdon ME, Gan S, Yaffe K, et al. - Researchers conducted this cross-sectional analysis to determine the prevalence and medication constituents of polypharmacy among older persons with dementia (PWD) attending outpatient visits in the United States.PWD and persons without dementia (PWOD) aged ≥ 65 years who attended outpatient visits recorded in the nationally representative National Ambulatory Medical Care Survey, 2014–2016. The unweighted sample included 918 PWD visits and 26,543 PWOD visits, representing 29.0 and 780 million outpatient visits. Polypharmacy was extremely common among PWD in a representative sample of outpatient visits, driven by a wide range of medication categories. Addressing polypharmacy in PWD will necessitate multidisciplinary and cross-cutting approaches.