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Polymorphisms in the H19 gene and the risk of lung cancer among female never smokers in Shenyang, China

BMC Cancer Sep 20, 2018

Yin Z, et al. - The link between long non-coding RNA (lncRNA) H19 genetic polymorphisms (rs217727, rs2107425, rs2735469 and rs17658052) and the susceptibility of lung cancer was evaluated in this case-control study including 556 female never-smoked lung cancer patients and 395 cancer-free controls. Researchers performed unconditional logistic regression analysis to assess the links between four single nucleotide polymorphisms and lung cancer risks by calculating the odds ratios and their 95% confidence intervals. According to findings, the polymorphism rs2107425 in H19 gene was related to the risk of lung cancer among females who never smoked in Shenyang, China. A statistically significant increased risk of lung cancer was observed among the carriers of the rs2107425 TT genotype vs carriers carrying homozygous CC genotype.

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