Callender T, Emberton M, Morris S, et al. - Experts developed a mathematical model that simulated hypothetical cohorts of 4.48 million men aged 55 to 69 years in England to investigate the benefit–harm tradeoffs and the cost-efficiency of a risk-tailored screening program vs age-based and no screening. According to findings, offering screening to men at greater risk could possibly decrease overdiagnosis and enhance the benefit–harm tradeoff and the cost-efficiency of a prostate cancer screening program. Moreover, the optimal threshold will rely on societal judgments of the relevant balance of benefits–harm and cost-efficiency, noted the investigators.