Li Z, Wu X, Leo PJ, et al. - Compared with CRP, sacroiliac MRI or HLA-B27 status alone, polygenic Risk Score (PRS) have a higher discriminatory capacity for ankylosing spondylitis (AS). For optimal performance, PRS should be developed for use in the specific ethnic groups to which they are to be applied.

• PRS had a high discriminatory capacity with the area under the curve (AUC) in receiver operator characteristic analysis of 0.924 in people of European descent.

• It was shown that this was significantly better than for HLA-B27 testing alone (AUC=0.869), MRI (AUC=0.885), or C-reactive protein (AUC=0.700).

• According to the findings, PRS developed and validated in individuals of East Asian descent performed similarly (AUC=0.948).

• The findings illustrated that PRS provides higher positive values for 35% of patients and negative predictive values for 67.5% of patients, assuming a prior probability of AS of 10% such as in patients with chronic back pain under 45 years of age in comparison with HLA-B27 testing alone.

• The results showed that for PRS, the maximum positive predictive value was 78.2% and negative predictive value was 100%, whereas for HLA-B27, these values were 51.9% and 97.9%, respectively, in people of European descent.