Sariya S, Felsky D, Reyes-Dumeyer D, et al. - This study sought to develop and validate a polygenic risk score for late-onset Alzheimer's Disease (LOAD) in Caribbean Hispanics (CH). A CH discovery (N=4,312) and independent validation sample (N=1,850) were used to construct an ancestry-specific polygenic risk score (“CH-PRS”) and assessed its performance alone and with other predictors using the area under the curve and logistic regression (strength of association with LOAD and statistical significance). Researchers investigated whether CH-PRS predicted conversion to LOAD in a subsample with longitudinal data (N=1,239). CH-PRS was also tested in an independent replication CH cohort (N=200) and brain autopsy cohort (N=33). The outcomes imply that in genetic studies, enriching diversity is critical to provide an effective PRS in profiling LOAD risk across populations.