Barr PB, Kuo SIC, Aliev F, et al. - Researchers explored if an association exists between genome-wide polygenic scores (GPS) for alcohol consumption and alcohol misuse. In addition, they determined how these GPS are affected by romantic relationships (gene–environment interaction; G × E) and if gender influence G × E results. They assessed data of 1,201 young adults (aged 20–26 years) from an intensively studied subset of Finnish Twin Study (FinnTwin12) for this work. Findings support the predictive value of GPS for drinking frequency, intoxication frequency and alcohol dependence (AD) symptoms. The association between genetic predisposition and drinking, high-risk drinking and alcohol problems reduced in correlation with being in a romantic relationship. However, only males displayed the protective effect for high-risk drinking, mapping onto earlier findings suggesting that romantic partnerships are more beneficial for males.