Hu G, et al. - Researchers determined the impact of podoplanin-positive cancer-associated fibroblasts (CAFs) on the prognosis in lung cancer patients via this meta-analysis including 12 published studies with 1,802 patients identified from PubMed and EBSCO. Findings revealed a significantly reduced overall survival (OS), disease-free survival (DFS), and progression-free survival due to podoplanin+ fibroblast infiltration in patients. Stratified analyses showed in both squamous cell carcinoma and adenocarcinoma of lung a significant association of podoplanin+ fibroblast infiltration with worse OS and DFS. In addition, a significant correlation of high density of podoplanin-positive CAFs with unfavorable clinicopathological features, like lymph node metastasis, and lymphatic, vascular, and pleural invasion was observed. Overall, a worse clinical outcome resulting from podoplanin+ fibroblast infiltration was evident. This indicates that it is a valuable prognostic biomarker and targeting it may have promise for effective treatment.