Vulliamy P, et al. - The intent here was to characterize the effects of platelet transfusion on platelet aggregation and fibrinolytic markers during hemostatic resuscitation. It was discovered that the available hemostatic resuscitation strategies did not restore platelet aggregation during active hemorrhage. The stored platelets could, nevertheless, attenuate fibrinolysis by providing an additional source of plasminogen activator inhibitor-1. The effects of early platelet transfusion on platelet function, hemostatic, and clinical outcomes during bleeding were yet to be explored.