Xian H, Luo D, Wang L, et al. - In the current study, researchers explored the effects of platelet-rich plasma (PRP)-incorporated autologous granular bone grafts for treatment in the precollapse stages (Association of Research Circulation Osseous (ARCO) stage II–III) of posttraumatic osteonecrosis of the femoral head (ONFH). Among a total of 46 eligible patients, core decompression and PRP-incorporated autologous granular bone grafting were performed in 24 patients (treatment group: 9 female and 15 male; age range, 16–39 years), and core decompression and autologous granular bone grafting were performed in 22 patients (control group: 6 female and 16 male; age range, 18–42 years). Outcomes support the safety and efficacy of procedure PRP-incorporated autologous granular bone grafting for treatment in the precollapse stages (ARCO stage II–III) of posttraumatic ONFH. The treatment group and the control group had a minimum clinically important difference for the HHS in 91.7% and 68.2% patients, respectively. Compared with the control group, the treatment group had significantly higher HHS at the last follow-up, had significantly declined VAS score, had more patients with successful clinical results and successful radiological results, and had higher survival rates based on the requirement for further hip surgery as an endpoint.