De Pergola G, et al. - In this study including a apparently healthy population represented by overweight and obese subjects with normal glucose and glycated hemoglobin (HbA1c) levels, including 240 subjects, 177 women and 63 men, aged 18–70 years, researchers assessed the link between platelet number and glucose metabolism, evaluated by HbA1c levels. They assessed body mass index (BMI), waist circumference (WC), systolic and diastolic blood pressure levels, platelet count and fasting blood glucose, insulin, insulin resistance, HbA1c, uric acid, triglyceride, total cholesterol, high and low density lipoprotein cholesterol concentrations. For the first time, they found a strong positive and independent link between HbA1c and platelet number in non-diabetic overweight and obese subjects. In a final multiple regression analysis, they observed a significant and independent positive association of HbA1c, female sex, and diastolic blood pressure and negative association of age and systolic blood pressure, with platelet count.