Bassi MS, et al. - Whether cerebrospinal fluid (CSF) platelet-derived growth factor (PDGF) concentrations at the time of diagnosis may impact the clinical course of relapsing-remitting multiple sclerosis (RR-MS), was determined. A positive correlation was noted between CSF PDGF levels and prolonged relapse-free survival. PDGF concentrations were shown to have no impact on radiological markers of disease activity, biochemical markers of neuronal damage, and clinical parameters of disease progression. Higher CSF PDGF levels were found to be related to an anti-inflammatory milieu within the central nervous system. Overall, a more prolonged relapse-free period, during the course of RR-MS, could be promoted by PDGF, with no effect on inflammation reactivation and inflammation-driven neuronal damage and likely enhancement of adaptive plasticity.