Ren Q, Chan KW, Huang H, et al. - Given that difficulty is faced in achieving an accurate early diagnosis of NK/T-cell lymphoma-associated hemophagocytic syndrome because of the variable overlap of various symptoms, which makes the prognosis extremely poor, and the hemophagocytic lymphohistiocytosis-2004 diagnostic criteria is now primarily used to diagnose hemophagocytic syndrome (HPS) and platelet count remains one of the baseline assessments, researchers addressed this matter in this study, revealing that reduced platelets were identified as not merely a clinical characteristic of HPS but also as the chief cells that regulate inflammation by releasing α-granules containing upregulated platelet factor 4 (PF4) and downregulated platelet-derived growth factors (PDGFs). Less reporting of angiopoietin-4 (ANG-4), which has significant differential expression, was also revealed, with a possible influence of ANG-4 on hematopoiesis and proinflammatory responses as well as its possible utility as diagnostic biomarkers combined with PF4 and PDGFs.