Platelet activation is a preoperative risk factor for the development of thromboembolic complications in patients with continuous-flow left ventricular assist device
European Journal of Heart Failure May 03, 2018
Consolo F, et al. - In patients implanted with a HeartMate II, HeartMate 3, or HeartWare HVAD continuous-flow left ventricular assist device (cf-LVAD), researchers assessed the correlation between the dynamics of platelet activation and the development of thromboembolic events. There was an association between thrombotic events and altered platelet activity state (PAS) values. Furthermore, patient-specific tendency to post-implant thromboembolic complications is suggested by baseline elevated PAS values in patients who developed thrombotic events. The development of refined patient-tailored antithrombotic strategies and the technological improvement of LVAD design might be guided by systematic monitoring of PAS.
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