Vecchiola A, García K, González-Gómez LM, et al. - In a general population, PAI-1 and adiponectin had the most robust relationships with metabolic syndrome (MetS) components, showing that poor adipose tissue performance is a major contributor to these metabolic anomalies.

• It was a cross-sectional study.

• According to Harmonizing ATP III, 202 participants were categorized into MetS and No-MetS.

• MetS patients had higher amounts of pro-inflammatory molecules but significantly lower levels of adiponectin than No-MetS individuals.

• Among the adipocytokines investigated, PAI-1 and adiponectin had the strongest correlations with the majority of MetS components.

• PAI-1 was found to be linked with MetS, whereas adiponectin was found to be inversely associated with MetS.

• In a multivariate analysis, the link between PAI-1 and adiponectin with MetS remained significant after adjusting for gender, age, BMI, and 24-hour urine sodium excretion.

• Multivariate analyses validated a model in which PAI-1, hsCRP, and MMP2 could predict systolic blood pressure; PAI-1 could predict diastolic blood pressure and glucose; PAI-1 and hsCRP could predict waist circumference.

• According to ROC curve analysis, a PAI-1 concentration had the highest sensitivity and specificity for distinguishing people with MetS.