Focusing on plasmacytoid (PCV) bladder cancer patients, researchers herein investigated how radical cystectomy (RC) and chemotherapy affect non-metastatic (T 2–4N0–3M0), as well as metastatic (TanyNanyM1) subgroups.

• A total of 332 PCV patients with muscle-invasive disease or higher (≥ T2N0M0) were identified by used the Surveillance, Epidemiology and End Results database (2000–2016).

• In non-metastatic PCV patients, lower cancer-specific mortality (CSM) was recorded in correlation with receiving RC, however, no effect of chemotherapy was evident.

• Conversely, metastatic PCV patients had statistically significantly lower CSM in correlation with both chemotherapy and RC.