Takata Y, et al. - In this case-control study, researchers explored the link between pre-diagnostic plasma selenoprotein P (SELENOP) concentration and lung cancer risk by analyzing data of 403 cases and 403 individually-matched controls nested within the Shanghai Men’s Health Study. By sandwich ELISA, SELENOP concentration in pre-diagnostic plasma samples was measured. The results of this study of Chinese men living in selenium non-deficient areas in China offer little support for the inverse relationship between pre-diagnostic plasma SELENOP concentration and lung cancer risk. However, even though there were a limited number of cases, plasma SELENOP concentration was positively correlated with lung adenocarcinoma risk, but not with lung squamous cell carcinoma, which should be cautiously interpreted.