Lind L, et al. - Researchers analyzed 870 participants in the PIVUS (Prospective Investigation of Uppsala Seniors Study) cohort, to examine common etiological pathways for 3 major cardiovascular diseases (CVD), as reflected in multiple proteins. In these participants, 84 proteins were measured on 3 occasions (age 70, 75, and 80 years). The sample was observed for incident myocardial infarction, ischemic stroke or heart failure. Assessing links with the 3 outcomes separately in a meta‐analysis of the 2 cohorts, 6 proteins were identified to be associated with incident myocardial infarction, 25 were related to heart failure, and 8 proteins to ischemic stroke after adjustment for conventional risk factors. Associations with all 3 CVDs were shown by growth differentiation factor 15 and tumor necrosis factor‐related apoptosis‐inducing ligand receptor 2. Some of these links were attenuated when estimated glomerular filtration rate was included in the models. On adjusting for conventional risk factors, 15 proteins were associated with a composite of all 3 CVDs employing a discovery/validation approach. Herein, links of multiple proteins with incident CVD were unveiled as well as validated. Association with all 3 diseases (myocardial infarction, ischemic stroke, and heart failure) was demonstrated by only a few proteins.