Plasma omega-3 polyunsaturated fatty acids and recurrence of endometrial cancer
BMC Cancer Jun 24, 2020
Li P, Shan B, Jia K, et al. - In order to determine the correlations of plasma polyunsaturated fatty acids (PUFAs) with endometrial cancer (EC) recurrence and all-cause mortality, researchers assessed 202 women with histologically confirmed EC who underwent surgery in Fudan University Shanghai Cancer Center between July 2008 and November 2013 and had enough plasma samples at time of surgery. During a median follow-up time of 58 months after surgery, they identified a total of 13 recurrences and 11 all-cause deaths, of which, 2 deaths from EC. Findings revealed correlation of higher plasma EPA with higher risk of EC recurrence. No significant association was observed between other omega-3 PUFAs, including ALA, DPA, DHA, with recurrence of EC. The associations between omega-3 PUFAs and recurrence were not significantly influenced by the age at diagnosis, menopause status, gravidity, stage, and grade.
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