Lécuyer L, et al. - In this investigation involving 211 incident breast cancer cases and 211 matched controls, researchers ascertained if untargeted metabolomic signatures from blood draw of healthy women could contribute to better understand and anticipate the long-term risk of developing breast cancer. Investigators found that a lower plasma level of O-succinyl-homoserine and higher plasma levels of valine/norvaline, glutamine/isoglutamine, 5-aminovaleric acid, phenylalanine, tryptophan, γ-glutamyl-threonine, ATBC and pregnene-triol sulfate were linked to a raised risk of developing breast cancer during follow-up. They concluded that several pre-diagnostic plasmatic metabolites were related to long-term breast cancer risk and proposed a role of microbiota metabolism and environmental exposure.