Xu M, Li S, Zhu J, et al. - Experts aspired to explore whether plasma lipid concentrations are causally correlated with the risk of primary open angle glaucoma (POAG) by applying two-sample Mendelian randomization (MR) analysis. Two-sample MR analysis of data from a genome-wide association study (GWAS) was conducted to examine the causal role of plasma lipid levels and POAG. In total, 185 independent single-nucleotide polymorphisms (SNPs) associated with plasma lipid levels were chosen as instrumental variables (IVs). No evidence for a causal association between plasma lipid levels and POAG risk was found in the present study. Further research is required to illustrate the potential biological mechanisms to provide a reasonable interpretation for these outcomes.