Nass KJ, et al. - The current study examined the effect of nonalcoholic fatty liver disease (NAFLD) on plasma lecithin:cholesterol acyltransferase (LCAT) and phospholipid transfer protein (PLTP) activities. For the purpose of this investigation, plasma LCAT activity and PLTP activity were determined in 348 subjects. Findings revealed that NAFLD, as inferred from an FLI ≥ 60, confers higher plasma LCAT and to a lesser extent PLTP activity, even when taking account of type 2 diabetes (T2DM), metabolic syndrome (MetS), central obesity and insulin resistance.