Kwon OC, Lee EJ, Oh JS, et al. - This research was attempted to assess if the plasma level of immunoglobulin binding protein 1 (IGBP1) can prognosticate future development of lupus nephritis (LN) in systemic lupus erythematosus (SLE) patients without nephritis. Researchers enrolled 43 SLE patients without nephritis (follow up period was 5 years). ELISA was applied to assess plasma IGBP1 levels, and clinical and laboratory data were collected at study entry. They conducted Cox regression analysis to distinguish factors correlated with development of LN, and receiver operating characteristic curve analysis was applied to ascertain the predictive value of each factor. For detection of SLE patients, plasma IGBP1 can be applied complementarily with anti-dsDNA Ab at a higher risk of developing LN.