Flahault A, Bollée G, El-Jalbout R, et al. - In this study, young adults born preterm exhibited higher plasma copeptin (a surrogate marker for vasopressin levels), and an association of plasma copeptin with a more severe neonatal course and smaller kidney volume was revealed.

• This is a case-control study of 101 adults born very preterm (<30 weeks of gestation) and 105 control adults born full-term.

• Median (IQR) copeptin levels in the preterm and the term groups were 8.2 (6.3, 12.4) and 6.1 (4.3, 9.0) pmol/l, respectively, in males; and were 5.2 (3.9, 7.6) and 4.0 (2.8, 5.7) pmol/l in females in the respective groups.

• Further elevation in copeptin levels was seen in adults born preterm with history of bronchopulmonary dysplasia.

• The preterm group showed smaller kidney volume, adjusted to height, and higher albuminuria, and both of these were related to higher plasma copeptin levels.