Lin T, et al. - In this nested case-control study, researchers analyzed the prospective association of baseline plasma 25(OH)D concentrations with cancer risk, as well as possible effect modifiers. Study participants were 231 subjects with incident cancer during a median 4.5 years of follow up, and 231 matched controls from the China Stroke Primary Prevention Trial (CSPPT). Risk of cancer has an inverse relationship with plasma 25(OH)D. Among Chinese hypertensive adults, low plasma 25(OH)D concentrations (<15.1ng/mL) were related to increased total cancer risk vs higher 25(OH)D concentrations. Plasma vitamin E concentrations and alcohol intake were identified potential effect modifiers.