Shainker SA, Silver RM, Modest AM, et al. - Researchers examined plasma protein profile of women with placenta accreta spectrum vs control individuals. Sixteen participants with placenta accreta spectrum and 10 control women with similar gestational ages (35.1 vs 35.5 weeks gestation, respectively) provided plasma samples before delivery. Participants with placenta accreta spectrum exhibited dysregulation of many proteins. Observations here indicated a unique and distinct plasma protein signature in participants with placenta accreta spectrum. The placenta accreta spectrum cases can be distinguished from control cases with the use of the top 21 proteins in placenta accreta spectrum. The following four proteins, which were dysregulated in placenta accreta spectrum vs control cases, were confirmed using enzyme-linked immunosorbent assay: median antithrombin III concentrations (240.4 vs 150.3 mg/mL), median plasminogen activator inhibitor 1 concentrations (4.1 vs 7.1 ng/mL), soluble Tie2 (13.5 vs 10.4 ng/mL), soluble vascular endothelial growth factor receptor 2 (9.0 vs 5.9 ng/mL).