Garg R, Cooke M, Benavides F, et al. - Researchers focused on the function of PKCϵ (an oncogenic kinase highly expressed in non–small cell lung cancer [NSCLC] and other cancers) in KRAS-driven tumorigenesis. PKCϵ expression was related to poor outcome in patients suffering from lung adenocarcinoma, particularly in those harboring KRAS mutations, as shown in database analysis. The need of PKCϵ for Kras-driven lung tumorigenesis in vivo was shown by a PKCϵ-deficient, conditionally activatable allele of oncogenic Kras (LSL-Kras^G12D; PKCϵ^−/− mice). This was found to be consistent with impaired transformed growth noted in PKCϵ-deficient KRAS-dependent NSCLC cells. Little overlap for PKCϵ and KRAS in the control of genes and biological pathways relevant in NSCLC was shown in mechanistic analysis employing RNA sequencing. This indicates the likely involvement of nonredundant mechanisms in a permissive role of PKCϵ in KRAS-driven lung tumorigenesis. Overall, the relevance as well as the potential of targeting PKCϵ for lung cancer therapeutics was highlighted.