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Pituitary adenoma consistency: Direct correlation of ultrahigh field 7T MRI with histopathological analysis

European Journal of Radiology Apr 17, 2020

Yao A, Rutland JW, Verma G, et al. - In the present study, researchers investigated the utility of 7 T (7 T) MRI in predicting the tumor consistency (a critical factor in surgical planning that influences ease of resection and risk of operative morbidity) of pituitary adenomas. Preoperatively, they scanned 15 patients with pituitary adenomas at 7 T MRI. Tumors, that were hyperintense to gray matter on 7 T T2-weighted imaging, were rated as soft . Correlation was observed between percentage of hyperintense tumor voxels and tumor collagen content. They observed a positive correlation of SI ratio with tumor cellularity and collagen content. Findings thereby suggest that valuable preoperative information regarding pituitary tumor consistency and physiology could be gained via the signal and contrast advantage conferred by 7 T MRI. The potential afforded by the high resolution of 7 T imaging maximizes with the use of granular, voxel-based analysis, and this may be a valuable approach for predicting consistency of pituitary adenoma.

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