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Physical frailty and decline in general and specific cognitive abilities: The Lothian Birth Cohort 1936

Journal of Epidemiology and Community Health Nov 08, 2019

Gale C, et al. – In this investigation involving 950 members of the Lothian Birth Cohort 1936, researchers assessed the link between physical frailty and initial level of, as well as the alteration in, cognitive abilities from age 70 to 79 years. The Fried criteria were applied to determine physical frailty at age 70 years. At ages 70, 73, 76 and 79 years, evaluation of cognitive function was done. Findings revealed a link of physical frailty, but not of prefrailty, with lower baseline levels of visuospatial ability, memory, processing speed and general cognitive ability, following control for age, sex, education, depressive symptoms, smoking, and number of chronic illnesses. Greater decline in each cognitive domain was observed in relation to physical frailty. Overall, experts concluded physical frailty as a possible vital indicator of age-associated decline across multiple cognitive domains.

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