Wogksch MD, et al. - In survivors of childhood Hodgkin lymphoma (HL), researchers characterized fitness and connected health-related quality of life (HRQoL) by analyzing data of 336 adult survivors of childhood-onset HL treated at St. Jude Children's Research Hospital and 327 controls who never had childhood cancer. Using a multivariable linear and logistic regression, associations were analyzed between chronic disease and fitness and between fitness and HRQoL. Findings suggested an association of moderate, severe/disabling, or life-threatening neurological conditions with impaired quadriceps strength and impaired endurance. An association of quadriceps strength, endurance, and neuropathy with a lower physical component summary on the HRQoL was reported. Outcomes revealed that survivors of childhood HL, especially those with cardiac, neurological, and pulmonary chronic conditions, were at risk for impaired fitness and HRQoL.