Phillips NS, Howell CR, Lanctot JQ, et al. - Among acute lymphoblastic leukemia (ALL) survivors, the link between exercise intolerance and neurocognitive impairments was examined in this study. Participants were 341 adult survivors of childhood ALL and 288 controls. Researchers used multivariable modeling to examine links between oxygen uptake at 85% estimated heart rate and neuropsychological examination and self-reported questionnaire domains, adjusted for gender, age at diagnosis, cranial radiation, anthracycline, and methotrexate exposure and tobacco smoking status. Adjusted models revealed the link of exercise intolerance with reductions in performance of verbal ability, focused attention, verbal fluency, working memory, dominant motor speed, nondominant motor speed, visual-motor speed, memory span, reading academics, and math academics among survivors. Overall, findings revealed a link between exercise intolerance and neurocognitive results.