Rees-Punia E, et al. - In the Cancer Prevention Study-II Nutrition Cohort, researchers assessed the links of moderate-to-vigorous physical activity [MVPA; metabolic equivalent hours/week (MET)-h/wk] and sitting (h/d) with the risk of myeloid neoplasms (MN) or MN subtypes. The HRs (95% CI) for meeting physical activity guidelines (7.5– < 15 MET-h/wk MVPA) and risk of MN and for doubling guidelines (15– < 22.5 MET-h/wk) were 0.74 and 0.75, respectively, compared with insufficient MVPA [> 0– < 7.5 MET-h/wk]; however, no statistically significant link for higher MVPA (22.5 + MET-h/wk) was identified. Similarly, a lower risk of myelodysplastic syndromes (MDS) was reported in correlation with meeting/doubling guidelines, but no link for 22.5 + MET-h/wk was found. Findings revealed no link between MVPA and risk of myeloid leukemia or acute myeloid leukemia. Also, no link was identified between sitting time and risk of any outcome. In this study, a possible nonlinear link between MVPA and risk of MDS and perhaps other MN was suggested.