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Phthalates and sex steroid hormones among men from NHANES, 2013-2016

Journal of Clinical Endocrinology and Metabolism Feb 05, 2020

Woodward MJ, et al. - Researchers aimed at examining the relationships between the urinary phthalate metabolites and serum sex steroid hormone concentrations in a nationally representative sample of adult males. From the 2013-2016 National Health and Nutrition Examination Survey performed among 1,420 male participants aged ≥ 20 years, data were retrieved for this cross-sectional analysis. As per results, males may be vulnerable to different phthalate metabolites in age-specific ways. Among men age ≥ 60, there was a correlation of high molecular weight phthalates with lower total, free, and bioavailable testosterone. Particularly, each doubling of Σdi-2-ethylhexyl phthalate (DEHP) was linked with 7.72% lower total testosterone among older men. Among men age 20-39, low molecular phthalates were noted to be linked with lower total, free, and bioavailable testosterone and among men age ≥ 40, Σ1,2-cyclohexane dicarboxylic acid di-isononyl ester (DINCH) was correlated with lower total testosterone.
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