Gulias-Cañizo R, Benatti A, De Wit-Carter G, et al. - In this observational cohort study, researchers sought to examine the effectiveness of photoactivated chromophore corneal collagen cross-linking (PACK)-CXL in the management of treatment-resistant infectious keratitis. The sample consisted of 41 patients (42 eyes) with treatment-resistant infectious keratitis. The success rate was 90.5% in the third postoperative month. Statistical analyses exhibited a significant effect of (PACK)‑CXL with standard antimicrobial therapy to reduce corneal ulcer size. PACK-CXL improves the outcomes in patients with treatment-resistant corneal ulcers as adjuvant therapy to standard antimicrobial treatment.