Francuzik W, Ruëff F, Bauer A, et al. - Researchers utilized data from the European Anaphylaxis Registry, to assess the phenotype as well as the risk factors of venom-induced anaphylaxis (VIA). They compared 3,612 patients with VIA with gender- and age-matched anaphylaxis cases triggered by other elicitors (non-VIA cases [n = 3,605]). The involvement of more than 3 organ systems was more common in VIA, and VIA was related to cardiovascular symptoms. Experts have validated, in this large cohort of VIA cases, that there exists a higher risk of severe VIA in patients with intermediate baseline serum tryptase levels (8-11 ng/mL) and without skin involvement. A higher risk of experiencing severe cardiovascular symptoms (including cardiac arrest) was observed in patients taking β-blockers or angiotensin-converting enzyme inhibitors in VIA and non-VIA cases. Epinephrine receipt was less frequent in patients with VIA vs cases with non-VIA.