Hainsworth JD, et al. - The combination of pemetrexed and carboplatin is a standard first-line treatment for patients with advanced NSCLC. In this current study, the feasibility of preoperative neoadjuvant pemetrexed and carboplatin for patients with localized NSCLC was assessed. Researchers found that it was feasible to administer 4 courses of pemetrexed/carboplatin. In terms of efficacy, similar results were similar to those seen with neoadjuvant regimens previously investigated. Surgical resection was not performed after neoadjuvant therapy, as reported in a significant number of patients 19 of 46 (41%) in this trial.