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Phase I study and biomarker analysis of pyrotinib, a novel irreversible pan-ERBB receptor tyrosine kinase inhibitor, in patients with human epidermal growth factor receptor 2–positive metastatic breast cancer

Journal of Clinical Oncology Nov 10, 2017

Ma F et al. -The safety, tolerability, pharmacokinetics, anti-tumor activity, and predictive biomarkers of pyrotinib in patients with HER2–positive metastatic breast cancer were determined In the current study it was shown that daily pyrotinib was well-tolerated with good anti-tumor activity in HER2-positive patients with metastatic breast cancer. The maximum tolerated dose was shown to be 400 mg.

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