Sveinsson O, Andersson T, Mattsson P, et al. - Researchers performed a nationwide case-control study in Sweden to test the assumption that antiepileptic drugs (AEDs) mono- or polytherapy, adherence, antidepressants, neuroleptics, β-blockers, and statins are correlated with a sudden unexpected death in epilepsy (SUDEP) risk. Two hundred fifty-five SUDEP cases and 1,148 matched controls were included. According to results, polytherapy, particularly taking 3 or more AEDs, was linked to a substantially reduced risk of SUDEP. Combinations including lamotrigine, valproic acid, and levetiracetam were related to reduced risk. A decreased risk of SUDEP was associated with statin use, but selective serotonin reuptake inhibitor use was not. Such findings support the importance of drug adherence and intensified AED therapy for patients with poorly controlled generalized tonic-clonic seizures in the effort to reduce the risk of SUDEP and indicate that comedication with statins can reduce the risk.