Le J, et al. - This paper explored the pharmacokinetics of single-dose ceftaroline fosamil in children with cystic fibrosis (CF). As the children with CF reported increased ceftaroline Clearance (CL) compared with published data from non-CF children, greater dosages could be needed in the children with CF. This would yield adequate exposure in the treatment of MRSA pneumonia. Pharmacodynamic-based dosing speculated that dosing ought to be based on the patient's MRSA MIC.