Huang K, Zhen Y, Li G, et al. - Researchers sought to determine the clinical results of pharmacokinetic (PK)-guided prophylaxis in 46 boys suffering from severe haemophilia A. A five-point assay was employed to conduct PK tests. Applying WinNonlin software, calculation of PK parameters was done. During the observation span, dosing regimen and bleeding rates were recorded. According to findings, quality of life-improvement in haemophiliac patients can be conferred by PK-guided prophylaxis by reducing bleeds with appropriate coagulation factor VIII consumption and decreasing infusion frequency without increases in bleeds, hence optimizing haemophilia management.