Child J, et al. - Pediatric patients with appendicitis given metronidazole once daily were studied to determine if this dosing would meet target area under the curve (AUC)/minimum inhibitory concentration (MIC) ratio of ≥70 for Bacteroides fragilis. After a 30 mg/kg per dose of intravenous metronidazole, 100 pediatric patients aged 4–17 years had an average of 3 blood draws per patient during the first 24 hours. Findings revealed that in these patients, metronidazole, 30 mg/kg per dose, once daily achieved AUC target attainment for B fragilis with an MIC of 2 mcg/mL or less. This study and the studies in adults did not suggest any pharmacokinetics-pharmacodynamics advantage of more frequent dosing in this population.