Martin O, Schaarschmidt BM, Kirchner J, et al. - PET/MRI and PET/CT were compared regarding the efficacy in lesion detection and classification in oncologic whole-body examinations. In addition, radiation exposure differences between the 2 modalities were determined. Researchers conducted an observational single-center study including 1,003 oncologic examinations (918 patients; mean age, 57.8 ± 14.4 y). Patients underwent PET/CT followed by PET/MRI (149.8 ± 49.7 min after tracer administration). Per analysis, PET/MRI was comparable to PET/CT in staging and led to improvement in lesion detectability in selected cancers, potentially allowing to promote fast, efficient local and whole-body staging in 1 step, when additional MRI is recommended. In addition, PET/MRI may be beneficial for younger patients given its reduced radiation exposure. For whole-body PET/CT, the estimated mean effective dose amounted to 17.6 ± 8.7 mSv vs 3.6 ± 1.4 mSv for PET/MRI, resulting in a potential dose reduction of 79.6%.