Moletta L, et al. - Researchers retrospectively assessed their experience of second primary cancer incidentally detected during Positron Emission Tomography/computed tomography (PET/CT) examination performed for pancreatic diseases, during the initial work-up or follow-up after surgical resection. Patients were followed for 29 months. Findings showed that as in other malignancies, in patients having PET/CT investigation for pancreatic diseases, the occurrence of unexpected FDG (Fluorodeoxyglucose) uptake can be found. A malignancy was likely to be found at locations showing focal uptake and hence deserve further investigations, however, considering the stage and the poor prognosis of primary pancreatic cancer was recommended. Survival benefit may be seen with aggressive treatment of incidental lesions in some selected patients.